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Physical exercise is any bodily activity that enhances or maintains physical fitness and overall health and wellness. It is performed for various reasons including strengthening muscles and the cardiovascular system, honing athletic skills, weight loss or maintenance, as well as for the purpose of enjoyment. Frequent and regular physical exercise boosts the immune system, and helps prevent the ?diseases of affluence? such as heart disease, cardiovascular disease, Type 2 diabetes and obesity.[1][2] It also improves mental health, helps prevent depression, helps to promote or maintain positive self esteem, and can even augment an individual?s sex appeal or body image, which is also found to be linked with higher levels of self esteem.[3] Childhood obesity is a growing global concern[4] and physical exercise may help decrease some of the effects of childhood and adult obesity. Health care providers often call exercise the ?miracle? or ?wonder? drug?alluding to the wide variety of proven benefits that it provides

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TRAINING: A typical day is training in the morning, either ground work or sparring, then in the afternoon I do strength and conditioning, and in the night I do either wrestling or standup. When and why did you start training for fighting? I started training when I was 16; I only did ground at first, [...]

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TRAINING: I train three times a day, six days a week When and why did you start training for fighting? When I was three years old. My father was a professional fighter and owned a Karate school. All the kids in our family started training at age three. What ranks and titles have you held? [...]

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Monday, April 2, 2012

Mechanism found connecting metastatic breast cancer and arthritis

New research shows it may be no accident when doctors observe how patients suffering from both breast cancer and arthritis seem to have more aggressive cancer. However, the new-found interaction between the two diseases may also suggest a possible treatment.

A potential relationship between metastatic breast cancer and autoimmune arthritis, as suggested by past epidemiological studies, has led researchers from the University of North Carolina at Charlotte to perform a series of mouse model experiments that appear to confirm the connection.

"Epidemiological studies have implied that breast cancer survival is significantly lower in patients who also had autoimmune arthritis," noted Pinku Mukherjee, Irwin Belk Distinguished Scholar of Cancer Research at UNC Charlotte, whose lab conducted the experiments. "As there is no obvious reason this should be so, we were interested in exploring possible cancer mechanisms that might explain why."

The experiments point to an intimate relationship between mast cells ? immune system cells that are located in various tissues and that can cause inflammation ? and metastatic tumors.

In previously published studies, UNC Charlotte cancer researcher Lopamudra Das Roy and her mentor Mukherjee established that breast cancer associated metastases were significantly higher in arthritic mice, with a threefold increase in lung metastases and a twofold increase in bone metastases.

In their most recent work, the researchers found that mast cells and their associated inflammation are present in larger numbers in the bones and lungs of arthritic mice than they are in non-arthritic mice. Their findings point to a relationship between the cKit receptor found on mast cells and the transmembrane stem cell factor (SCF) ligand found on metastatic breast cancer cells. The interaction between SCF and cKit appears to play a critical role in facilitating metastasis.

"We confirmed the relationship we suspected between autoimmune disease and metastastic breast cancer cells," Mukherjee said. "This is an exciting result for us because it confirms an interesting interdependence between cancer metastasis and a specific component of the immune system."

The study results will be presented by Lopamudra Das Roy, Research Assistant Professor at UNC Charlotte, and Mukherjee at the 2012 American Association for Cancer Research Annual Meeting in Chicago at a press conference on April 1.

The researchers worked with two strains of mice. The first group had spontaneous arthritis (SKG mice) and the second group of mice had spontaneous breast cancer (MMTV-PyV MT mice). Each of the mouse strains were artificially induced to develop the other disease and then tested for differences.

Among the findings of the analysis was that the population of mast cells within bone and lung microenvironment was significantly higher in those mice with arthritis and breast cancer vs. those without arthritis and breast cancer. The differentiation of mast cells from bone marrow derived stem cells was also significantly higher in the arthritic versus the non-arthritic tumor-bearing mice.

Mast cells are the only "terminally differentiated" (mature) cells in the body that develop, like blood cells, from stem cells in the bone marrow and that also have a c-Kit receptor. Suspecting a relationship between the c-Kit receptor on the mast cells and the SCF ligand expressed by the metastatic cancer cells, the researchers tested the effect of blocking receptor by treating the mice with an anti-c-Kit receptor antibody and celecoxib, an anti-inflammatory medication.

"When the mice were treated with a therapy to target the c-Kit mast cell receptor in combination with celecoxib -- a drug used to treat autoimmune arthritis -- the incidence of breast cancer metastasis to the bone and lung was greatly reduced," Das Roy noted.

The researchers conclude that in an arthritic condition, SCF expression in metastatic breast cancer cells induces the differentiation of mast cells from bone marrow through SCF/CKit signaling. Mast cells, in turn, facilitate the efficient metastasis of the breast cancer cells in bone and lung tissue. Autoimmune arthritis disease increases the intensity of metastatic breast cancer because bone marrow stem cells in autoimmune arthritis victims have greater potential to develop into mast cells.

In future studies, the researchers plan to examine the presence of mast cells in human tumor samples.

Provided by University of North Carolina at Charlotte

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Though driving is inherently dangerous, drivers and passengers have seatbelts, airbags, and reinforced frames to keep them safe. Pedestrians, on the other hand, are especially vulnerable in the event of an accident. If you are ever struck by a car while walking on the street and suffer personal injuries, you should know your rights:

The right of way:

As long as you?re on the sidewalk or in a legal crosswalk, you have the legal right of way. Even if you cross the street illegally, motorists are by no means legally allowed to hit you. When a motorist encroaches on your right of way, he is neglecting the rules of the road. If you suffer a serious injury as a result of that negligence, you may be able to hold that motorist legally responsible for all damages.

The right to medical care:

It?s recommended to seek medical attention immediately after an accident, even if you lack the insurance to pay for treatment. If you file a personal injury claim, you may be reimbursed for all expenses, including medical bills. Shortly after the accident, you?ll likely be contacted by your own insurance company or that of the driver who hit you. It?s important that you refer all claims adjusters to your lawyer and instead focus on your recovery. ?

The right to an attorney:

For help putting your life back together, you should hire a skilled personal injury attorney as soon as possible. After reviewing the circumstances of the accident, your personal injury attorney will help you negotiate a reasonable settlement with the offending driver. If a settlement cannot be reached, your attorney will then argue on your behalf in court. ?

If you have been the victim of a pedestrian accident, call The Carlson Law Firm. After reviewing your case, our skilled personal injury attorneys will help you obtain compensation for medical bills, missed wages, loss of quality of life, and other damages. Call us today at (877) 217-3696 to schedule an initial consultation.

Disclaimer:

The materials available at this website are for informational purposes only and not for the purpose of providing legal advice. You should contact your attorney to obtain advice with respect to any particular issue or problem. Use and access to this website or any of the links contained within the site do not create an attorney-client relationship. The opinions expressed at or through this site are the opinions of the individual author and may not reflect the opinions of the firm or any individual attorney.?

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Benefits Of Bike Ridings From Health Perspective

In this modern era, people have become busy due to their hectic life style and overloaded work schedule. In such circumstances, bicycle or bike ridings have become very popular across the world. Peoples use to feel that it?s one of the funniest and entertaining ways to maintain your health in comparison to various other kinds of workouts and exercises. Apart from that, it also helps you in sharing roads in heavy traffic in your city with cars, trucks, sports utility vehicles (SUVs) along with many other vehicles. For this, you must have knowledge of traffic rules so that you could make a ride with a bicycle or bike on the road as per your convenience.

Bike riding has several advantages from health perspective over the other traditional approaches that people use in terms of workouts or exercises.

Although, people can enjoy it in a very funny and entertaining way, however they have to learn basics of riding under supervision of a trainer. You should never try to ride a bike or a bicycle on the road without getting trained properly. If you do so, you may always be in danger. Hence, you should never avoid training in any situations. If you are thinking to provide training for cycle riding for your kids, you should go for a reputed academy which has been involving in providing bike riding training for many years.

In recent times, there are numerous training academies available where anyone can learn the basics of riding as per their custom needs and requirements, that too within their financial budget. These training academies have fully professional and experienced trainers who can teach basics as well as security and safety tips of bike or bicycle riding to anybody whether they are kids, children, teenagers or youngsters.

These kinds of riding can be learnt in step by step. You can?t get trained in one, two or three days, it takes some time. Before taking admission in any training academy, you must confirm about their learning process as well as their reputation in the market that they have been gained over the time.

You should always go for one of the most reputed institutes that are known for their Excellency in providing bike or cycle riding training in a fully professional way. Moreover, their fees should also be affordable for you. You must enquire these things properly according to your special needs and requirements. After getting fully satisfaction, you can go for bike riding training.

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Sunday, April 1, 2012

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